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Cathy C Zhang Selected Research

nirogacestat

10/2018Synergistic antitumor effect of a γ-secretase inhibitor PF-03084014 and sorafenib in hepatocellular carcinoma.
1/2017Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1-Stat3.
6/2014Comparison of dynamic contrast-enhanced MR, ultrasound and optical imaging modalities to evaluate the antiangiogenic effect of PF-03084014 and sunitinib.
3/2013Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models.
9/2012Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models.

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Cathy C Zhang Research Topics

Disease

8Neoplasms (Cancer)
10/2018 - 11/2010
2Hepatocellular Carcinoma (Hepatoma)
10/2018 - 01/2017
2Neoplasm Metastasis (Metastasis)
01/2017 - 09/2012
2Breast Neoplasms (Breast Cancer)
03/2013 - 09/2012
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2018
1Tics (Tic)
03/2013
1Triple Negative Breast Neoplasms
03/2013
1Burkitt Lymphoma (Burkitt's Lymphoma)
01/2013
1Lymphoma (Lymphomas)
01/2013
1Colorectal Neoplasms (Colorectal Cancer)
01/2013

Drug/Important Bio-Agent (IBA)

5Amyloid Precursor Protein Secretases (beta-Secretase)IBA
10/2018 - 09/2012
5nirogacestatIBA
10/2018 - 09/2012
2Docetaxel (Taxotere)FDA Link
03/2013 - 01/2013
2Biomarkers (Surrogate Marker)IBA
01/2013 - 09/2012
1Sorafenib (BAY 43-9006)FDA Link
10/2018
1Phosphotransferases (Kinase)IBA
10/2018
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
10/2018
1Gemtuzumab (Mylotarg)FDA Link
01/2018
1Immunoconjugates (Immunoconjugate)IBA
01/2018
1Gamma Secretase Inhibitors and ModulatorsIBA
01/2017
1Sunitinib (Sutent)FDA Link
06/2014
1SurvivinIBA
03/2013
1alovudineIBA
01/2013
1AntigensIBA
01/2013
1Indicators and Reagents (Reagents)IBA
01/2013
1LuciferasesIBA
01/2013
1Tissue ExtractsIBA
01/2013
1Sirolimus (Rapamycin)FDA Link
01/2013
12- amino- 8- (4- (2- hydroxyethoxy)cyclohexyl)- 6- (6- methoxypyridin- 3- yl)- 4- methylpyrido(2,3- d)pyrimidin- 7(8H)- oneIBA
01/2013
1Messenger RNA (mRNA)IBA
09/2012
1ThymidineIBA
03/2012
1Cadherins (E-Cadherin)IBA
11/2010
1PF-03732010 monoclonal antibodyIBA
11/2010
1Membrane Glycoproteins (Membrane Glycoprotein)IBA
11/2010
1Monoclonal AntibodiesIBA
11/2010

Therapy/Procedure

6Therapeutics
10/2018 - 11/2010
2Aftercare (After-Treatment)
06/2014 - 09/2012
1Induction Chemotherapy
01/2018
1Microbubbles
06/2014
1Drug Therapy (Chemotherapy)
01/2013